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| Title: | SCANNING FORCE MICROSCOPY STUDY OF ACTIVATED HUMAN PLATELETS SHAPE CHANGE | |
| DOI No: | 10.1142/9789812701947_0054 | |
| Source: | PHYSICS, CHEMISTRY AND APPLICATION OF NANOSTRUCTURES (pp 243-246) | |
| Author(s): | L. V. KUKHARENKO
Belarusian State Medical University, 83, Dzerzhinskii Ave., 220116 Minsk, Belarus V. G. LESHCHENKO Belarusian State Medical University, 83, Dzerzhinskii Ave., 220116 Minsk, Belarus H. FUCHS Westfälische Wilhelms-Universität, Wilhelm-Klemm-Str. 10, D48149 Münster, Germany A. B. SAMAL Belarusian State University, 4, Fr.Scaryna Ave., 220050 Minsk, Belarus |
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| Abstract: | We report here on the platelet surface morphology changes and platelet aggregation as a function of time after addition of 10-5 M ADP and 5·10-3 M H2O2 to cause reversible platelet aggregation by scanning force microscopy. Different stages of the platelet shape change from the initial formation of filopodes to slowly reverting back to discoid shape platelets were investigated. The periodical chain-like structure with irregular size of 40-55 nm and fiber structure with the width of ~ 3 nm on the filopodia surface were observed. Analysis of the activated platelet surface morphology reveals details of the cytoskeleton rearrangement. | |
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