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| Title: | ENALAPRIL PRESERVES SINUS NODE FUNCTION IN A CANINE BRADYCARDIA-TACHYCARDIA SYNDROME MODEL | |
| DOI No: | 10.1142/9789812702234_0012 | |
| Source: | ADVANCES IN ELECTROCARDIOLOGY 2004 (pp 59-62) | |
| Author(s): | MASAO SAKABE
The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical, University, 2630 Sugitani, Toyama, Japan AKIRA FUJIKI The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical, University, 2630 Sugitani, Toyama, Japan KUNIHIRO NISHIDA The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical, University, 2630 Sugitani, Toyama, Japan MASATAKA SUGAO The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical, University, 2630 Sugitani, Toyama, Japan TAKAYUKI TSUNEDA The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical, University, 2630 Sugitani, Toyama, Japan KOICHI MIZUMAKI The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical, University, 2630 Sugitani, Toyama, Japan HIROSHI INOUE The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical, University, 2630 Sugitani, Toyama, Japan |
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| Abstract: | The aim of this study was to investigate effects of enalapril on sinus node dysfunction associated with atrial fibrillation. Eighteen beagles were pretreated with placebo (Group-I, n=10) or enalapril 1mg/kg/day (Group-II, n=8). In group-I, 4 weeks of rapid atrial pacing prolonged corrected sinus node recovery time (CSNRT) in dogs without AV ablation (from 281.3 ± 27.8 to 811.3 ± 52.4 ms, p<0.05). Enalapril significantly shortened CSNRT (409.8 ± 37.2 ms, p<0.005) compared with Group-II by suppressing fibrosis around the sinus node (9.2 ± 9.1% v.s 2.2 ± 2.3%, p<0.05). These findings suggest the suppression of fibrosis around SN by enalapril may play an important role to preserve sinus node function in bradycardia-tachycardia syndrome. | |
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