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| Title: | VENTRICULAR REPOLARIZATION ABNORMALITY IN JAPANESE CARRIERS OF G643S SINGLE NUCLEOTIDE POLYMORPHISM OF KCNQ1 GENE | |
| DOI No: | 10.1142/9789812702234_0035 | |
| Source: | ADVANCES IN ELECTROCARDIOLOGY 2004 (pp 131-133) | |
| Author(s): | TOMOYA OZAWA
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa Seta, Otsu City, Shiga Pref. 520-2192, Japan MAKOTO ITO Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa Seta, Otsu City, Shiga Pref. 520-2192, Japan SHINJI TAMAKI Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa Seta, Otsu City, Shiga Pref. 520-2192, Japan TAKENORI YAO Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa Seta, Otsu City, Shiga Pref. 520-2192, Japan TAKASHI ASHIHARA Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa Seta, Otsu City, Shiga Pref. 520-2192, Japan YOSHIKUNI KITAT Department of Health Science, Shiga University of Medical Science, Tsukinowa Seta, Otsu City, Shiga Pref. 520-2192, Japan HIROTSUGU UESHIMA Department of Health Science, Shiga University of Medical Science, Tsukinowa Seta, Otsu City, Shiga Pref. 520-2192, Japan MINORU HORIE Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa Seta, Otsu City, Shiga Pref. 520-2192, Japan |
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| Abstract: | The common SNP (G643S) of KCNQl was identified in patients with secondary long QT syndrome. We reported that this Snip caused a reduction in KCNQ1 current and may be associated with QT prolongation in specific Japanese families. To evaluate, in the general population, the relationships between the genotypes and phenotypes, we examined in 993 general subjects. In hetero-group (HG) (G643S), QT, Tpe, and Tpec intervals were significantly longer. This Snip, moreover, might partially play on the bradycardiac tendency in HG. | |
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