| Home | Organizers | Proceedings Editors | Proceedings Contributors | Search | | ||
|
|
|||
|
||||
|
|
||||
| Title: | SHOCK-INDUCED CHANGES IN TRANSMEMBRANE POTENTIAL: WHAT IS THE ASYMMETRY DUE TO? INSIGHTS FROM BIDOMAIN SIMULATIONS
This work is supported by NIH grants HL063195 and HL067322. |
|
| DOI No: | 10.1142/9789812702234_0042 | |
| Source: | ADVANCES IN ELECTROCARDIOLOGY 2004 (pp 143-147) | |
| Author(s): | TAKASHI ASHIHARA
Department of Biomedical Engineering, Tulane University, Boggs Center, Suite 500, New Orleans, Louisiana 70118, U.S.A. Department of Physiology and Biophysics, Kyoto University Graduate School of Medicine, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan NATALIA TRAYANOVA Department of Biomedical Engineering, Tulane University, Boggs Center, Suite 500, New Orleans, Louisiana 70118, U.S.A. |
|
| Abstract: | There are discrepancies between simulations and experiments in the transmembrane potential changes (ΔVm) by strong electric shocks. We found that the experimentally-observed (i) negative bias in ΔVm, asymmetry (asymmetry ratio ≈ 2), (ii) rectangularly-shaped positive ΔVm, (iii) electroporation occurring at the anode only, and (iv) increase in positive ΔVm, caused by the L-type Ca2+-channel blockade were reproduced in the model by the addition of electroporation and a hypothetical outward current, the latter assumed to be part of the K+ flow through the L-type Ca2+-channel. | |
| Full Text: | View full text in PDF format (281KB) | |
| TOC: | Back to Table of Contents | |
|
||