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| Title: | ASSESSMENT OF LOCAL REPOLARIZATION CHANGES USING MODEL BASED BSPM INTERPRETATION | |
| DOI No: | 10.1142/9789812702234_0047 | |
| Source: | ADVANCES IN ELECTROCARDIOLOGY 2004 (pp 158-162) | |
| Author(s): | MILAN TYSLER
Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia MARIE TURZOVA Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia SLAVOMIRA FILIPOVA Institute of Cardiovascular Diseases, Bratislava, Slovakia |
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| Abstract: | Possibility to assess local repolarization changes in the heart using body surface potential maps and dipole model of corresponding cardiac sources was analyzed on simulated data and tested on a group of 11 patients that underwent PTCA of a single vessel. Differences between QRST integral maps before and after the intervention were interpreted as being caused by additional dipolar source representing the region with changed action potentials. In a simulation study, lesions created as regions comprising 3–12% of the myocardium volume caused rms differences in integral maps 10–45%. These were proportional to action potential shortening and/or amplitude decrease in subendocardial lesions while transmural lesions produced smaller differences. Single dipoles represented the changes in integral maps with rms error <24% and their positions, orientations and dipole moments well reflected the locations and extents of simulated lesions, except for some transmural lesions. In 8 of 11 studied patients, interventions caused significant changes in QRST intergral maps (rms differences > 36%) that could be represented by single dipole with rms error less than 57%. In 7 of them estimated dipole positions approximately matched with the treated heart regions. Results suggest that the model-based interpretation of difference integral maps could be a useful tool to identify small, not transmural regions with changed repolarization. | |
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