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| Title: | SHORT TERM MEASURES OF HEART RATE VARIABILITY | |
| DOI No: | 10.1142/9789812702234_0050 | |
| Source: | ADVANCES IN ELECTROCARDIOLOGY 2004 (pp 174-181) | |
| Author(s): | EILIDH HODGART
University of Glasgow, Div of Cardiovascular and Medical Sciences, Royal Infirmary, Glasgow G31 2ER, Scotland, UK ELAINE CLARK University of Glasgow, Div of Cardiovascular and Medical Sciences, Royal Infirmary, Glasgow G31 2ER, Scotland, UK SHAHID LATIF University of Glasgow, Div of Cardiovascular and Medical Sciences, Royal Infirmary, Glasgow G31 2ER, Scotland, UK PETER W MACFARLANE University of Glasgow, Div of Cardiovascular and Medical Sciences, Royal Infirmary, Glasgow G31 2ER, Scotland, UK |
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| Abstract: | Depressed heart rate variability (HRV) has been shown to be a powerful prognostic indicator in patients following acute myocardial infarction (MI). Most measures of HRV are derived from the 24hr ECG but this method is time-consuming. This study looked specifically at HRV, measured over 10s from a resting 12-lead electrocardiogram, and compared values in normal volunteers with those from patients following MI. 10-second resting 12-lead ECGs were obtained from 56 apparently healthy volunteers and 49 post-MI patients. All subjects were in sinus rhythm. The standard deviation of normal-to-normal R-R intervals (SDNN) was calculated. Patients were followed up for 30 days. The normal range for 10s SDNN was 14–187ms. Medians and interquartile ranges for healthy volunteers and patients were 46.65ms (42.94) and 18.74ms (27.94) respectively for 10s SDNN (p-value for difference <0.001) Adjusting the lower limit of normal to the 6th percentile (94% specificity), the sensitivity of 10s SDNN as a test of abnormal HRV in post MI patients was 47%. Survival analysis over 30 days showed no statistical difference in probability of an event (death or CABG) between patients with high and low HRV values using this 6th percentile as a cut-off. Nonetheless, the acceptable sensitivity/specificity of 10s measures as a marker of abnormal HRV is encouraging and suggests that larger studies of 10s HRV be done to consider its incorporation into routine 12-lead ECG recording. | |
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