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| Title: | FUNCTIONAL DEVELOPMENT OF Ca2+ SIGNALING PATHWAYS IN MOUSE EMBRYONIC STEM CELLS DURING DIFFERENTIATION TO CARDIOMYOCYTES | |
| DOI No: | 10.1142/9789812702234_0056 | |
| Source: | ADVANCES IN ELECTROCARDIOLOGY 2004 (pp 219-229) | |
| Author(s): | SEIKO KAWANO
Dept. of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan Brain Science Institute, RIKEN, Wako, Japan SATOSHI SHOJI Brain Science Institute, RIKEN, Wako, Japan AKINORI KURUMA Brain Science Institute, RIKEN, Wako, Japan YOSHIYUKI HIRAYAMA Dept. of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan KEISHI OTSU Dept. of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan ERI YANAGIDA Dept. of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan YUKO MUTO Dept. of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan FUMIO YOSHIKAWA Brain Science Institute, RIKEN, Wako, Japan TEIICHI FURUICHI Brain Science Institute, RIKEN, Wako, Japan |
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| Abstract: | Embryonic stem (ES) cells are pluripotent cells and able to differentiate in vitro into a variety of cell types including cardiac myocytes (1,2). Many studies of derived cardiomyocytes from mouse ES cells provide important information for understanding the early stages of development in heart, such as the expression of cardiac-specific genes, proteins, receptors and functional development of ion channels (2, 3, 4). Cardiomyocytes derived from mouse ES cells have been demonstrated a time-dependent expression of ion channels and signal transduction pathways in electrophysiological studies (3). Several recent studies have also suggested that cardiomyocytes derived from ES cells would be useful for the cell transplantation therapy in defective heart diseases (5, 6). However, the detailed mechanisms for functional developments of Ca2+ signaling tool kits, such as Ca2+ channels, Na+/K+ ATPase and Na+/Ca2+ exchangers have not been well understood. In this study, we focus the functional developments of Ca2+ signaling pathways in mouse ES cells during differentiation to cardiomyocytes. | |
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