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| Title: | A MATHEMATICAL MODEL OF THE PROPOSED FUZZY SPACE FOR NA+ AND CA2+ IN LEFT VENTRICLE CARDIOMYOCYTES | |
| DOI No: | 10.1142/9789812702234_0060 | |
| Source: | ADVANCES IN ELECTROCARDIOLOGY 2004 (pp 246-249) | |
| Author(s): | G. T. LINES
Simula Research Laboratory, PB 134, 1325 Lysaker, Norway P. GRØTTUM Medical Faculty, University of Oslo, Norway JØRN B. SANDE Ullevål University Hospital, University of Oslo, Norway TÆVJE A. STRØMME Ullevål University Hospital, University of Oslo, Norway OLE M. SEJERSTED Ullevål University Hospital, University of Oslo, Norway |
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| Abstract: | The sodium-calcium exchanger increases intracellular calcium when it operates in reverse mode. In pathological conditions with elevated sodium this calcium source might contribute sufficiently to facilitate contraction. We propose a mathematical model where the spatial and temporal distribution of sodium and calcium is taken into account. Important channels are represented as spatially discrete entities. Under certain conditions we observe in the model that release from SR can be triggered by sodium influx and thus advanced in time. However, the present results are preliminary and in order to draw quantitative conclusions several modeling uncertainties must be clarified. | |
| Full Text: | View full text in PDF format (229KB) | |
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