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| Title: | COMPARATIVE EFFECTS OF INSULIN AND INSULIN-LIKE GROWTH FACTOR-1 ON DOG VENTRICULAR MUSCLES AND RABBIT CARDIOMYOCYTES
The present study was supported by grants from National Science Council (NSC-92-2320-B016-037 and NSC91-2317-B002-009) and Cheng-Hsin Rehabilitation Medical Center (93-02), Taipei, Taiwan, ROC. |
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| DOI No: | 10.1142/9789812702234_0063 | |
| Source: | ADVANCES IN ELECTROCARDIOLOGY 2004 (pp 252-256) | |
| Author(s): | C. H. HSU
Institutes of Medical Sciences, Medicine, National Defense Medical Center, 161, Minchuan E. Road, Sec. 6, Neihu 114, Taipei, Taiwan, R.O.C. C. -I LIN Physiology, National Defense Medical Center, 161, Minchuan E. Road, Sec. 6, Neihu 114, Taipei, Taiwan, R.O.C. Pharmacology, Departments of Medicine, National Defense Medical Center, 161, Minchuan E. Road, Sec. 6, Neihu 114, Taipei, Taiwan, R.O.C. Y. X. LOH Pharmacology, Departments of Medicine, National Defense Medical Center, 161, Minchuan E. Road, Sec. 6, Neihu 114, Taipei, Taiwan, R.O.C. Y. C. CHEN Biomedical Engineering, National Defense Medical Center, 161, Minchuan E. Road, Sec. 6, Neihu 114, Taipei, Taiwan, R.O.C. J. WEI Heart Center Cheng-Hsin Rehabilitation Medical Center; Taipei, Taiwan, R.O.C. S. Y. HU Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan, R.O.C. J. H. HUANG Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan, R.O.C. |
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| Abstract: | It has been demonstrated that the positive inotropic effects of insulin involve enhanced L-type Ca2+ currents and Na/Ca exchanger, activation of adenylyl cyclase signal pathway and increased release of Ca2+ from the sarcoplasmic reticulum. However, comparative actions of insulin-like growth factor-1 (IGF-I) versus insulin on cardiac muscles and cardiomyocytes have not been well evaluated. The aims of present experiments were to determine the effects of 10 nM ~ 10 μM insulin and IGF-I on isolated dog ventricular trabeculaes (at 37 °C) and rabbit ventricular myocytes. | |
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