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| Title: | CONVERSION AND MAINTENANCE EFFECTS OF SINUS RHYTHM BY BEPRIDIL IN PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION | |
| DOI No: | 10.1142/9789812702234_0085 | |
| Source: | ADVANCES IN ELECTROCARDIOLOGY 2004 (pp 327-329) | |
| Author(s): | YUJI NAKAZATO
Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan MASAYUKI YASUDA Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan AKITOSHI SASAKI Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan YOUJI IIDA Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan YASUNOBU KAWANO Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan KAORU NAKAZATO Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan TAKASHI TOKANO Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan HIROYUKI DAIDA Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan YORIAKI MINEDA Division of Cardiology, Juntendo-Izu Nagaoka Hospital, Shizuoka, Japan MASATAKA SUMIYOSHI Division of Cardiology, Juntendo-Izu Nagaoka Hospital, Shizuoka, Japan YASURO NAKATA Division of Cardiology, Juntendo-Izu Nagaoka Hospital, Shizuoka, Japan |
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| Abstract: | We administrated bepridil in 112 patients with persistent AF lasting an average of 5 months. In 65 of 112 patients (58%), sinus rhythm was restored within 6 months (average 2.1 months) following administration of bepridil. DC cardioversion was performed on 21 of the remaining 47 patients with unsuccessful pharmacological conversion, and all of those patients were restored to sinus rhythm. Eventually, of the total number of 86 patients who were restored to sinus rhythm by bepridil or DC cardioversion, 70 (82%) patients were maintained in sinus rhythm with a mean follow-up of 18 months. Bepridil showed favorable sinus conversion effect and was highly effective for maintaining sinus rhythm after pharmacological or electrical cardioversion. | |
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