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| Title: | EFFICACY AND SAFETY OF LOW DOSE AMIODARONE | |
| DOI No: | 10.1142/9789812702234_0090 | |
| Source: | ADVANCES IN ELECTROCARDIOLOGY 2004 (pp 344-347) | |
| Author(s): | YASUNOBU KAWANO
Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan YUJI NAKAZATO Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan AKITOSHI SASAKI Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan YOUJI IIDA Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan KAORU NAKAZATO Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan TAKASHI TOKANO Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan MASAYUKI YASUDA Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan HIROYUKI DAIDA Department of Cardiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan YORIAKI MINEDA Division of Cardiology, Juntendo-Izu Nagaoka Hospital, Shizuoka, Japan MASATAKA SUMIYOSHI Division of Cardiology, Juntendo-Izu Nagaoka Hospital, Shizuoka, Japan YASURO NAKATA Division of Cardiology, Juntendo-Izu Nagaoka Hospital, Shizuoka, Japan |
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| Abstract: | The efficacy and safety of low dose Amiodarone (AMD) therapy for supraventricular and ventricular arrhythmias was evaluated retrospectively in patients with cardiac dysfunction. AMD was given in eighty four patients (60 male, mean age 66±13.0 year old). Mean follow-up period was 15±14.1 months (6- 71). In our protocol, oral AMD was initially loaded 400 mg/day for 3 days and then maintained 100-200 mg/day. Follow-up examinations were performed before and after oral AMD (at 1, 3, 6 and every 6 months). Clinical efficacy for arrhythmias was evaluated by symptoms and ambulatory ECG. During follow-up period, arrhythmias were successfully suppressed in 66 (78.6%) of patients and its adverse effects were observed in 16 patients (19.0%). Although we had experienced a case of pulmonary toxicity, it was not lethal and there is no progression of pulmonary toxicity without recurrence of arrhythmias after reduction of AMD. AMD was discontinued in 6 patients because of neurological complication (2), liver dysfunction (2), and no efficacy (2). During follow-up period, mean serum concentration of AMD, DEA and KL-6 showed no significant changes. Although 17 patients died, there was no cardiac sudden death. In this study, low dose AMD therapy was effective for arrhythmias and safely administered with few serious complications. | |
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