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| Title: | INFLUENCE OF THE PREPARATION METHOD ON THE AMPICILLIN INCORPORATION IN HYDROTALCITE-LIKE COMPOUNDS | |
| DOI No: | 10.1142/9789812779168_0073 | |
| Source: | NANOPOROUS MATERIALS (pp 717-728) | |
| Author(s): | RODICA ZAVOIANU
University of Bucharest, Faculty of Chemistry, Department of Chemical Technology and Catalysis, Bd. Regina Elisabeta, No. 4-12, S3, Bucharest 030018, Romania OCTAVIAN DUMITRU PAVEL University of Bucharest, Faculty of Chemistry, Department of Chemical Technology and Catalysis, Bd. Regina Elisabeta, No. 4-12, S3, Bucharest 030018, Romania ANCA CRUCEANU University of Bucharest, Faculty of Chemistry, Department of Chemical Technology and Catalysis, Bd. Regina Elisabeta, No. 4-12, S3, Bucharest 030018, Romania MIHAELA FLOREA University of Bucharest, Faculty of Chemistry, Department of Chemical Technology and Catalysis, Bd. Regina Elisabeta, No. 4-12, S3, Bucharest 030018, Romania RUXANDRA BÎRJEGA National Institute for Physics of Lasers Plasma and Radiation, Bd. Atomistilor, 409, Bucuresti/Magurele, Romania ANDREI ROTARU National Institute for Physics of Lasers Plasma and Radiation, Bd. Atomistilor, 409, Bucuresti/Magurele, Romania CORINA BRADU University of Bucharest, Faculty of Chemistry, Department of Organic Chemistry and Environmental Protection, Sos. Pandurilor, No90-92, S5, Bucharest, Romania PETRE ROTARU University of Craiova, Faculty of Physics Str. A.I. Cuza, No. 1-13,Craiova, Romania |
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| Abstract: | The paper presents a comparison between the chemical and physicochemical properties of three hydrotalcite-like compounds containing ampicillin (HT3A) prepared by different methods of i.e.: a) impregnation of the dried HT3(HT3AI); b) reconstruction of the HT3 structure by immersion of the mixed oxide obtained by calcination of HT3 at 460°C in an aqueous solution of ampicillin sodium salt (HT3AR); c) direct synthesis at pH 10, using aqueous solutions of Mg and Al nitrates and a base solution of ampicillin (HT3AS). The obtained results lead to the conclusion that the reconstruction method and the direct synthesis allowed the incorporation of the highest amount of ampicillin. Since both the structure of ampicillin and the hydrotalcite are less altered when using the reconstruction method it was concluded that this preparation technique is more suitable for the sustained release formulation. | |
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